Vampires and werewolves have waged a nocturnal war against each other for centuries. But all bets are off when a female vampire warrior named Selene, who's famous for her strength and werewolf-hunting prowess, becomes smitten with a peace-loving male werewolf, Michael, who wants to end the war. Selene, a vampire warrior, is entrenched in a conflict between vampires and werewolves, while falling in love with Michael, a human who is sought by werewolves for unknown reasons.