Blank-faced bug killer Bill Lee and his dead-eyed wife, Joan, like to get high on Bill's pest poisons while lounging with Beat poet pals. After meeting the devilish Dr. Benway, Bill gets a drug made from a centipede. Upon indulging, he accidentally kills Joan, takes orders from his typewriter-turned-cockroach, ends up in a constantly mutating Mediterranean city and learns that his hip friends have published his work -- which he doesn't remember writing. After developing an addiction to the substance he uses to kill bugs, an exterminator accidentally kills his wife and becomes involved in a secret government plot being orchestrated by giant bugs in a port town in North Africa.